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Herb Friedman has passed away. Herb was the colum- began in and was ready for the CB boom he nist for our computer column. Herb made it a practice to test products for magazine reviews only; manufac- I first met Herb 30 years ago when we both were new to turers made offers for his service but he turned them magazine publishing. At impartial. He started out as the technician who lit the fuse cumbered. Herb enjoyed the inquisitive mind of the tronics Illustrated, Radio -TV News, students at the high school, and thus began his free- Electronics World, Elementary lance writing career so that he could reach out to the Electronics, Popular Mechanics, many others who shared the hunger for electronics Popular Science, Mechanics Illus- project building ideas.
Herb acquired test equipment to build an extensive will miss Herb. The entire staff will miss Herb. Our consumer -electronics testing laboratory.
He did consid- I readers, especially the emerging experimenters, will erable product testing in the seventies and became well miss Herb. European, and Japanese audio man- ufacturers.
Many years ago when it was popular to quote Adieu, Herb Friedman. The audio indus- try followed suit a year later.
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Granulocytic sarcomas may occur at diagnosis of AML or may precede the diagnosis; as the first manifestation of relapse in patients previously treated for primary or secondary acute leukemia. They have also been associated with myelodysplastic syndromes or myeloproliferative disorders and usually predict transformation to acute leukemia 3 , 4 , 5 , 6.
In almost all reported cases of primary Granulocytic sarcoma without a known pre-existing or concomitant acute leukemia , acute leukemia has developed shortly 2. The tumors are usually localized; they often involve bone, periosteum, soft tissues, lymph nodes, or skin.
The orbit and paranasal sinuses, gastrointestinal tract 7 , 8 , genitourinary tract, breast, cervix, salivary glands, mediastinum, pleura, peritoneum, and bile duct also have been reported 4.
The tissue biopsy for diagnosis is the preferred method 9.
The granulocytic sarcoma subclassified according to cell type into granulocytic, monoblastic or myelomonocytic and according to cell maturation into immature, mature and blastic types 5. Immunophenotying and immunohistochemistry or immunocytochemical are crucial for the accurate diagnosis of MS 6.
Immunophenotyping can be done either in paraffin section or via fluorescence-activated cell sorting analysis on cell suspension derived from the tumor. Pileri et al. After the diagnosis of MS, bone marrow aspiration and biopsy should be performed to rule out acute leukemia and other hematological malignancies 9. Magnetic resonance or computed tomography is performed to localize and rule out other differential diagnoses of the tumor.
These techniques also differentiate MS from abscess and hematomas especially in patients with AML