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Entire MIMS Manual (pdf). manualvpdf, MB Table of Contents. MIMS Reference Manual · Chapter 1: Toolbar · Chapter 2: Tuning · Chapter 3: Holder. PDF(doxylamine + pyridoxine): Learn about PDF's Dosage, Side Effects and indications. MIMS is the essential prescribing and drug reference guide. For over 50 years MIMS has provided medical professionals with information on.
Authors The Editorial Executive Committee welcomes letters, which should be less than words. Before a decision to publish is made, letters which refer to a published article may be sent to the author for a response. Any letter may be sent to an expert for comment. When letters are published, they are usually accompanied in the same issue by any responses or comments. The Committee screens out discourteous, inaccurate or libellous statements. The letters are sub-edited before publication.
It inhibits tubulin polymerization in the parasite and blocks glucose uptake. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Special Monitor blood counts and liver function. Drug Interactions Cimetidine increases albendazole metabolism.
Susceptible parasites include hookworm. Overdosage Symptomatic and supportive measures are advised. Mechanism of Albendazole exhibits a broad-spectrum anthelmintic activity Action showing vermicidal. Adverse Drug GI discomfort. Bone marrow depression. ALZAD tab. AL tab. Extensive hepatic first-pass metabolism. ALBEX tab. AH-1 susp. Note that there are some more drugs interacting with albendazole albendazole further details are available in official CIMS India albendazole albendazole brands available in India Always prescribe with Generic Name: ALBOL tab.
BANDY susp. ABZ susp. ABIDE tab. EBEX chewable tab. ALZOL tab. ALIO tab. Belongs to the class of Classification benzimidazole derivative agents used as antinematodal. C-TROP susp. EBEX susp. C-BEND tab. BIWOM susp. ABIDE syr. C-BAND film-coated tab. DAZO tab. AH-1 chewable tab.
AL susp. BANDY tab. ALBEX susp. E-BEND tab. ALZAD susp. C-TROP tab. BIWOM tab. BAND tab. D-WORM syr. Widely distributed. ABZ chewable tab.
Via bile. C-BEND syr. XENDA susp. ODAL tab. X-WORM susp. ZAA susp. ZAA tab. OLBAN tab. REALB syr. OBEN syr. ODAL susp. X-WORM tab. R-BEN susp. N-BEND susp.
REALB tab. REZOL tab. OLBAN susp. WONIL tab. WONIL susp. HYMIN susp. FOBEN chewable tab. XENDA tab. HYMIN tab. FOBEN susp. Oral Paget's disease of bone Adult: Swallow whole. Milk or antacids should be given to bind alendronate. Should not induce. Overdosage Symptoms may include hypocalcaemia.
Oral Corticosteroid-induced osteoporosis Adult: Treatment and prevention: Administration Should be taken on an empty stomach.
Oral Prophylaxis of postmenopausal osteoporosis Adult: Agents Affecting Bone Metabolism alendronic acid P. Reactions heartburn. Drug Interactions Concomitant iron. Dialysis would not be beneficial. Poorly absorbed from the GIT oral. Should not induce vomiting due to the risk of oesophageal irritation. Note that there are some more drugs interacting with alendronic acid alendronic acid.
Contraindications Hypocalcaemia. Patient should remain fully upright. Special Upper GI disorders discontinue if symptoms worsen. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Adverse Drug Oesophagitis. Mechanism of Alendronic acid reduces bone resorption by inhibiting the Action action of osteoclasts. Food Interaction Food. Correct vitamin D and calcium deficiency before starting therapy.
Symptoms may include hypocalcaemia. Used in the treatment of bone diseases. Belongs to the class of bisphosphonates. In hypercalcaemic dialysis patients. In case of renal impairment.
Treatment is symptomatic and supportive. Overdosage Symptoms may include anorexia. Rickets or osteomalacia. Adverse Drug Anorexia. Hypoparathyroidism Adult: Consider treatment with glucocorticosteroids.
Ensure patient is well hydrated by i. Monitor Precautions serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. ECG especially in patients on digitalis. Avoid in patients with hypersensitivity to inj. Premature infants and neonates: Stop admin of alfacalcidol. Renal osteodystrophy. Contraindications Hypercalcaemia. Monitor electrolytes. Used as dietary supplements. Note that there are some more drugs interacting with alfacalcidol alfacalcidol alfacalcidol brands available in India Always prescribe with Generic Name: Faeces and urine small amounts.
Belongs to the class of vitamin D and Classification analogues. Some antiepileptics e. Adequately absorbed from the GI tract oral. Adipose and muscle tissue. Mechanism of Alfacalcidol is a precursor of the active calcitriol. It does not Action require renal hydroxylation but requires hydroxylation in the liver for conversion to calcitriol.
Specific to a-globulin. Drug Interactions Thiazides may increase the risk of hypercalcaemia. ALFA-D3 tab. ALFEX cap. ALCAL cap. GSCAL tab. Adverse Drug Drowsiness. Mild-moderate impairment: Initiate with 2. Contraindications Severe hepatic impairment. Reactions depression. Special Elderly. Monitor BP regularly. Maintain patient in supine position to restore BP. Adjust dose according to response.
Modified-release preparations are not recommended. May affect ability to drive or operate machinery. Overdosage May lead to hypotension. Monitor renal function. Belongs to the class of Classification alpha-adrenoreceptor antagonists. Reduced serum levels when used with CYP3A4 inducers e. CYP3A4 inhibitors e. Extensively metabolised in the liver.
Note that there are some more drugs interacting with alfuzosin alfuzosin further details are available in official CIMS India alfuzosin alfuzosin brands available in India Always prescribe with Generic Name: Mechanism of Alfuzosin is a quinazoline-derivative which exhibits selectivity Action for a1 -adrenergic receptors in the lower urinary tract. FUAL tab. Metabolites are mainly excreted in faeces via bile.
Concurrent use with potent CYP3A4 inhibitors e. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate. EFZU extentab. Used in the treatment of benign prostatic hypertrophy. Readily absorbed after oral admin.
Up to mg may be taken as a single dose. Dose reduction may be needed. Severe impairment: Monitor liver function regularly. Oral Gout Adult: Max initial dose: Ensure adequate fluid intake. Dose is adjusted based on subsequent hr urinary urateexcretion.
Ensure sufficient fluid intake to produce a daily urinary output of at least 2 L and maintenance of a neutral. Therapy should be started hr before initiating the treatment. Oral Prophylaxis of uric acid nephropathy associated with cancer therapy Adult: Oral Recurrent calcium oxalate stones Adult: Intravenous Cancer therapy-induced hyperuricaemia Adult: Maintenance for patients with hyperuricaemia secondary to cancer or cancer therapy: Dose is titrated based on response.
GI disorders. Take immediately after meals. Dose can be given as a single dose or equally divided doses at Withdraw immediately when sensitivity skin rash. Reactions vomiting. Adverse Drug Rash. Prophylactically with an Precautions anti-inflammatory or colchicine for at least 1 mth. Therapy should be started hr before initiating the chemotherapy treatment. Amikacin sulfate. Special Ensure adequate fluid intake. May increase serum levels of ciclosporin. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid.
Converted to oxipurinol alloxanthine. Mechanism of Allopurinol is an inhibitor of the enzyme xanthine oxidase Action which converts hypoxanthine to xanthine then uric acid. After reconstitution: May prolong half-life of chlorpropamide and dicumarol. Drug Interactions Increased risk of skin rash when used with ampicillin or amoxicillin. May increase bone marrow depression when used with cyclophosphamide Potentially Fatal: Increased haematological effects of azathioprine and mercaptopurine when co-administered with allopurinol.
Powder for inj: The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Enters breast milk. Urine as unchanged drug and metabolite. Note that there are some more drugs interacting with allopurinol allopurinol further details are available in official CIMS India allopurinol. Belongs to the class of preparations Classification inhibiting uric acid production. Used in the treatment of gout. Solution should be used within 10 hr of preparation. URLO tab.
ORLU tab. ALUR tab. Z-NOL tab. GURIK tab. Sudden withdrawal of allyloestrenol should be avoided as it leads to intermittent breakthrough bleed lactation. Contraindicated in preg L. Adverse Drug GI disturbances. Belongs to the class of estren derivative progestoge Classification used in progestogenic hormone preparations.
It prepares the uterus fo Action receiving the fertilised ovum and suppresses uterine motility. Increased ciclosporin concentration. Drug Interactions Enhanced clearance with enzyme-inducing drugs eg. Special Discontinue medications if there is sudden partial or complete loss of vision. Lab Interference Alterations in lipid profile and liver function tests. Mechanism of Allylestrenol is similar to that of natural progesterone. History of depression. Precautions proptosis or diplopia. My impair ability to drive operate machinery.
Ket azole may increase bioavailability of progesterone. IUGR tab. ANIN tab. Note that there are some more drugs interacting with allylestrenol allylestrenol allylestrenol brands available in India Always prescribe with Generic Name: Take 30 mins before meals.
May lower blood glucose. Special Pregnancy and lactation. As a racemic mixture: It is also known as thioctic acid. Monitor Precautions blood glucose levels regularly. Mechanism of Alpha-lipoic acid has antioxidant activity and activity in Action enhancing biological energy production.
Anxiolytics alprazolam P. Avoid in severe impairment. Flumazenil may be used for complete or partial reversal of the sedative effects of benzodiazepines and may be used when an overdose with a benzodiazepine is known or suspected.
Oral Panic attacks Adult: Up to 10 mg daily. Monitor respiration. Contraindications Acute narrow-angle glaucoma. Dialysis is of limited value. Muscle weakness. General supportive measures and immediate gastric lavage may be recommended. Precautions Geriatric or debilitated patients. Special Dosage reduction or gradual withdrawal. If hypotension occurs. Mechanism of Alprazolam has anxiolytic. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.
It binds to the? Alprazolam enhances activity of imipramine anddesipramine. There is positive evidence of human foetal risk. Adverse Drug Psychological and physical dependence. Cimetidine and fluoxetine reduce the clearance of alprazolam. Used in the management of anxiety. Belongs to the class of Classification benzodiazepine derivatives anxiolytics. Urine as unchanged drug and metabolites. Well absorbed from the GIT oral. Geriatric or debilitated patients. Action antidepressant and sleep-modifying effects.
Note that there are some more drugs interacting with alprazolam alprazolam further details are available in official CIMS India alprazolam. Blood dyscrasias. Dosage reduction or gradual withdrawal.
BELFA tab. Q-REST tab. TAGAT tab. ANXIT tab. PACYL tab. AZO-O tab. DALP tab. MCALM tab. L-PEEZ tab. TRIKA tab. ALPRA tab. ALZEX tab. AZO-S tab. ALP tab. P-KALM tab. NOREX tab. LORAL tab. SOWEL tab. D tab. ALZY tab. ANAX tab. ALP-FT tab. TENAN tab. ALEP tab. RIAN tab. AZO-F tab. ANZI tab. ZAM tab. ALRIF tab. QUIET tab. STS tab. RESTA tab. ALAP tab. D SR-tab. AZOX tab.
ATAM tab. ATEEZ tab. ANZI-P tab. ALPAM tab. ANXYL tab. ZEPRO tab. ZOCAM tab. ZOLIN tab. ZOPIC tab. ZOPAX tab. ZOLAX tab. ZOLAM tab. ZENAX tab. Drugs for Erectile Dysfunction. Intracavernosal Diagnosis of erectile dysfunction Adult: Reduce to the lowest dose necessary to maintain response as soon as possible. Usual maintenance: Once the optimal dose is determined.
Other Cardiovascular Drugs alprostadil P. A dose of mcg may also be administered trans-urethrally. To be injected into a large vein. Intracavernosal Erectile dysfunction Adult: For neurogenic origin e. Urethral Erectile dysfunction Adult: Initially mcg.
Food Interaction Avoid ethanol. Rapidly metabolised by oxidation during passage through the pulmonary circulation. Reactions diarrhoea. Belongs to the class of drugs used in erectile dysfunction. When injected along the penile shaft. Mechanism of Alprostadil causes vasodilation and prevents platelet Action aggregation. Belongs to the class of prostaglandins used in cardiac therapy.
Note that there are some more drugs interacting with alprostadil alprostadil further details are available in official CIMS India alprostadil alprostadil brands available in India Always prescribe with Generic Name: Caution in COPD. Cardiac arrest. This allows blood flow to the lacunar spaces of the penis. Special Neonates receiving PGE1 for more than hr should be Precautions closely monitored for antral hyperplasia and gastric outlet obstruction.
Excreted in urine as metabolites within 24 hr. Adverse Drug Flushing. It has direct effect on the vascular and ductus arteriosus smooth muscle. Usual dose: Not to exceed a total dose of 4 mg. Intravenous Acute massive pulmonary embolism Adult: Total dose: First 10 mg as bolus.
Intravenous Acute ischaemic stroke Adult: To be given within 3 hr of the onset of symptoms: Infuse 0. Injection Clearance of central venous lines Adult: A total dose of mg should be given as soon as possible after the onset of symptoms. For admin within 6 hr of MI: Monitor intracranial Precautions haemorrhage and BP in acute stroke. Storage Injection: Lyophilised product: Reconstitute by adding 50 ml of sterile water for inj without preservatives to a vial containing 50 mg of drug using a large-bore e.
Contraindications Recent surgery or trauma. Final concentration: Renal impairment. Drug Interactions Heparin reduces risk of coronary reocclusion. Increased risk of hemorrhage with warfarin. Reconstituted solution: Use within 8 hr. Lab Interference May interfere with estimation of plasma fibrinogen and other coagulation tests. Mechanism of Alteplase initiates local fibrinolysis and dissolution of clots by Action binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin.
Haemorrhage esp with previous trauma or unsuspected underlying cause of bleeding. Adverse Drug Vomiting. Special Children.
Prostacyclin and nitrates increase plasma alteplase clearance. Belongs to the class of enzymes. Note that there are some more drugs interacting with alteplase alteplase alteplase brands available in India Always prescribe with Generic Name: Alteplase initiates local fibrinolysis and dissolution of clots by binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin.
Cleared rapidly from the plasma mainly by hepatic metabolism. Belongs to the class of other agents used as ophthalmologicals. Oral Hyperphosphataemia in patients with chronic renal failure Adult: Dose is adjusted to the individual patient's requirement. Adverse Drug Constipation. Food Interaction Food decreases gastric emptying time.
Special Chronic renal impairment. Up to 1 g daily. Fe salts.
Contraindications Hypersensitivity to aluminium salts. Decreases absorption of allopurinol. Mechanism of Alumunium hydroxide acts on the HCl in the stomach by Action neutralization. Alumunium hydroxide reacts with hydrochloric acid. Drug Interactions Enhanced absorption with citrates or ascorbic acid.
Absorbed aluminium is excreted via the urine. Belongs to the class of Classification aluminium-containing antacids. C-CID susp. N-CID gel. Insoluble aluminium salts formed in the intestines. Alumunium hydroxide reacts with hydrochloric acid in the stomach to form soluble aluminium chloride. OAM gel. Alumunium hydroxide acts on the HCl in the stomach by neutralization.
Note that there are some more drugs interacting with aluminium hydroxide aluminium hydroxide aluminium hydroxide brands available in India Always prescribe with Generic Name: PFT tab.
Used for the treatment of acid-related disorders. Oral Herpes zoster in immunocompromised patients Adult: Antivirals amantadine P. Antiparkinsonian Drugs. Oral Prophylaxis of influenza A Adult: It alters dopamine release and re-uptake. Lowest effective dose.
It also noncompetitively antagonises N-methyl-D-aspartate. Mechanism of Amantadine is a weak dopamine agonist possessing Action antimuscarinic properties. Adverse Drug Seizures. Epilepsy or other seizure disorders. Readily absorbed from the GIT oral. Special Patients with CV or liver disease. Crosses the placenta and the blood-brain barrier. Precautions recurrent eczema.
Overdosage Cardiac arrest may occur. Withdrawal of the drug should be gradual. Congestive heart failure. As an antiviral drug.
Drug Interactions Enhances the adverse effects of antimuscarinics and levodopa. Mainly via urine by glomerular filtration and tubular secretion as unchanged and small amounts of an acetylated metabolite. Oral Parkinson's disease Adult: CNS stimulants. Note that there are some more drugs interacting with amantadine amantadine amantadine brands available in India Always prescribe with Generic Name: Used in the management of parkinson's disease.
Belongs to the class of adamantine derivative dopaminergic agents. Reactions Mechanism of Ambroxol is a metabolite of bromhexine and is used Action similarly as a mucolytic. Adverse Drug Mild GI effects and allergic reactions. Used in the treatment of wet cough. Belongs to the class of mucolytics. OOX-LC syr. AMCOF syr. EXOL syr. ARCUF syr. DYL-AX tab. ALTEC syr. LCZ-XP liqd. HIS-P tab. OOX expectorant.
COFAL dry syr. DM film-coated tab. AMY expectorant. MAGS syr. EX-GTM syr. OOX-LC tab. LENEX tab. LCF syr. FESTA tab. ZYREX syr. XL cap. VAREX syr. TAG-M syr. XPAR-A liqd. SV-AS oralliqd. TEAM liqd. TAGS syr. Supportive Care Therapy amifostine P. Reconstitute with 9. Visual inspection for particulate matter and discoloration prior to admin is recommended. Intravenous Prophylaxis of xerostomia in patients undergoing radiotherapy for head and neck cancer Adult: Each single-use vial contains mg of anhydrous amifostine.
Overdosage May cause hypotension which can be managed by supportive care and normal saline infusion. Patients should be well-hydrated. Do not use if cloudiness or precipitate is observed. Vials containing lyophilized powder: Belongs to the class of detoxifying agents used in antineoplastic treatment. Dephosphorylated by alkaline phosphatase to an active metabolite. Mechanism of Amifostine is a prodrug that is converted to a Action pharmacologically active metabolite free thiol.
Patients should be well-hydrated Precautions and kept supine during infusion. Volume of distribution: Elimination half life after minute IV infusion: Prolonged infusion causes greater side effects: Stop antihypertensive drugs 24 hr before infusion. Reactions Transient and reversible loss of consciousness rarely. Admin antiemetics before infusion especially when emetogenic drugs are used. Severe skin reactions.
Systolic fall is greater. Adverse Drug Hypotension during infusion. Drug Interactions Concurrent use with antihypertensives may cause severe hypotension. M-FOST vial. Up to mg every 8 hr in life-threatening infections. Dosage adjustments may be made by a normal doses at increased dosing intervals or b reduced doses at the usual intervals.
Maintenance doses can be calculated by dividing the normal dose by the patient's serum creatinine. IV inj over minutes or as IV infusion. Max cumulative dose: Aminoglycosides amikacin P. For b. For a. Parenteral Severe Gram-negative infections resistant to gentamicin and tobramycin Adult: Doses may be given via IM. Reactions Potentially Fatal: Adverse Drug Tinnitus. Discontinue if signs of Precautions ototoxicity. Storage Parenteral: Detected in body tissues and fluids after inj.
Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. Drug Interactions Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together. Significant amounts penetrate the blood-brain barrier in children with meningitis.
Increased risk of ototoxicity with potent diuretics. Belongs to the class of antibiotics. Monitor renal function before and during treatment. Used in the treatment of systemic infections. Via the urine by glomerular filtration within 24 hr. Belongs to the class of other aminoglycosides. Mechanism of Amikacin binds to 30S ribosomal subunits of susceptible Action bacteria.
Overdosage Peritoneal dialysis or haemodialysis may be used in case of overdosage. Increased ototoxic or nephrotoxic effects with other nephrotoxic or ototoxic drugs. Enhanced neuromuscular blockade with neuromuscular blocking drugs. AMK vial. MINI inj. RICA inj. AKCIN vial.
MIKKA inj. AMIZA inj. EUMIK vial. Note that there are some more drugs interacting with amikacin amikacin amikacin brands available in India Always prescribe with Generic Name: SAK inj. PARK vial. Useful best medical websites, health blogs, medical forums,medical powerpoint presentations, medical mnemonics, free medical books , software , videos , journals, exam preparation tips, clinical skills, medical news,android applications,medical images, animations, medical entrance mcqs,usmle forums.
This book is mainly for asian countries, but am sure it will help others also There are also details about how overdosage and toxicity of the drugs are treated.
There is also a list of the common brands available in india for each generic drug. USE isilo reade r on your mobilephone to read this book You can also use Alternate mediafire link to download the cims book source: But I would appreciate a clickable linkback to http: Glad to work with u again for further book releases.
Dr John http: Thanks for the prompt linkback Aslam. I'm adding a page on banned drugs in India, and also drugs banned by UD FDA but allowed in India, as I feel it is an issue which needs widespread awareness.
If u have any suggestions, please leave a comment on my blog. Happy Onam. New version released. Smaller size by removing excess formatting tags 2. Thank you so much for you work. Helped out me a lot. Such things on net is keeping good things alive. AKZ management.