For this fourth edition of Stahl's Essential Psychophar- two “pips” macology you will . Torrent. There. Stephen M. University of Activity instructions Cambridge. Request PDF on ResearchGate | On Aug 1, , van den Heuvel and others published Stahl's Neuroscientific basis and practical applications (4th edition). Stahl's Essential Psychopharmacology presents the fundamentals of psychopharmacology and has established itself as the preeminent source.
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A one-stop shop, covering everything a doctor, teacher or trainee will ever need to know about neuropsychopharmacology. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (4th ed.) by Stephen M. Stahl. Read online, or download in secure PDF. Fourth Edition. With this fully revised Fourth Edition, Dr. Stahl returns to the essential Stahl, S. M.. Stahl's essential psychopharmacology: neuroscientific basis and practical . Manual) of the American Psychiatric Association or the ICD .
Unfortunately, Stahl does not address the controversies or the weaknesses of hypotheses; he merely presents the dominant view.
As an example, some 30 pages of the book are devoted to the glutamatergic hypothesis of schizophrenia. On the other hand, positive, negative, and cognitive symptoms are forcefully and in extreme detail argued to result from a completely opposite state: NMDA receptor hypofunction. Stahl does not reconcile these opposing stances; however, to judge from the depth of his coverage, he favors the latter mechanism.
Critically, the NMDA hypofunction hypothesis is heavily dependent on the finding that NMDA receptor antagonists such as PCP and ketamine better model the spectrum of schizophrenia symptoms than dopaminergic drugs such as amphetamine, or serotonergic drugs such as LSD.
However, Seeman points out that both PCP and ketamine have dopaminergic effects and may well induce psychosis through dopaminergic rather than glutamatergic mechanisms. If this is true, the entire NMDA hypofunction hypothesis falls flat on its face. To do Stahl justice, he does acknowledge in his preface that his intention is to simplify at the expense of precision.
Unfortunately, no reader would know what is a controversy and what is not. Who should read it?
While this book is not meant for serious psychopharmacologists who require in-depth discussions and extensive reference materials, it will certainly suit the needs of almost all students and academicians, and will also help practising clinicians understand more about the molecular mechanisms involved in health, and in illness and the treatment thereof. Very importantly, this book is the springboard from which the advanced student can take off to a deeper exploration of the field.
This book is strongly recommended to all students and teachers of psychiatry and psychopharmacology.
Clinicians who wish to understand the principles underlying their prescribing behavior will also benefit from a perusal of the book, particularly from the sections that deal with therapeutics and the differences between drugs for a particular indication.
All in all, this is a phenomenal piece of work from a single author.
Conflict of interest. Compared to previous editions, it may be of greater importance to read this book from start to finish in a linear fashion.
Another criticism which the author acknowledges, is that the material in the book is not referenced on a statement-by-statement basis, and often relies on tertiary sources such as textbooks. A suggested readings bibliography for each chapter is presented at the end of the book, but one would have trouble attributing a particular statement in the book to any one source. To be fair though, there is more primary literature cited than in previous editions.
Ownership of this text is highly recommended for those who prescribe, recommend, monitor, and work with psychiatric medications. National Center for Biotechnology Information , U. Author information Copyright and License information Disclaimer. Vancouver, British Columbia. This book belongs in every clinician's library and serves as a model of clarity for others. I recommend this text as an extremely useful reference work as we enter the next decade of discovery in brain neurosciences and its role in clinical psychiatry.
He has conducted various research projects awarded by the National Institute of Mental Health, the Veterans Administration and the pharmaceutical industry. Author of more than articles and chapters, Dr Stahl is the author of the bestsellers Stahl's Essential Psychopharmacology and The Prescriber's Guide.
Chemical neurotransmission; 2. Transporters, receptors and enzymes as targets of psychopharmacological drug action; 3.
Ion channels as targets of psychopharmacological drug action; 4. Psychosis and schizophrenia; 5. Antipsychotic agents; 6.