Katzung & Trevor's Pharmacology: Examination & Board Review, 12e. Bertram G. Katzung, Marieke Kruidering-Hall, Anthony J. Trevor. Go to Review Questions. Basic and Clinical Pharmacology 12/E (LANGE Basic Science) 12th Edition. by. Bertram G. Katzung (Author) Bertram G. Katzung (Author),. Susan B. Masters. Basic and Clinical Pharmacology (12th edition) PDF Download, By Bertram G. Katzung, ISBN: , The twelfth edition of Basic & Clinical.
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-Basic and Clinical Pharmacology 12th Edition=Bertram Katzung Susan Masters . Development & Regulation of Drugs Bertram G. Katzung, MD, PhD 69 Bertram G. Katzung, MD, PhD .. The twelfth edition of Basic & Clinical Pharmacology continues (Trevor AJ, Katzung BG, & Masters SB: McGraw-Hill, ). (Reproduced, with permission, from Katzung BG, editor: Basic & Clinical. Pharmacology, 12th ed. McGraw-Hill, Fig. 1–3.) High-Yield Terms to Learn .
The chapter-based approach facilitates use with course notes or larger texts. Concise discussion of the major concepts that underlie basic principles or specific drug groups in every chapter? Full-color tables and figures many new to this edition? Review questions followed by answers and explanations? Two comprehensive question practice exams, followed by answer keys and explanations for correct answers?
Although most of these local effects can be prevented by H2 receptor in their airways. Gastrointestinal tract smooth muscle—Histamine causes 9. Other effects possibly mediated by histamine contraction of intestinal smooth muscle, and histamine-induced receptors—In addition to the local stimulation of peripheral contraction of guinea pig ileum is a standard bioassay for this amine.
Burimamide, doses of histamine may cause diarrhea, partly as a result of this an early candidate for H2-blocking action, and newer analogs with effect.
This action of histamine is mediated by H1 receptors. Other smooth muscle organs—In humans, histamine gen- central nervous system.
Although the mecha- Selective H3 and H4 antagonists are not yet available for clinical nism of this action is not known, these compounds may represent use. However, potent and partially selective experimental H3- an important new class of analgesics.
Some of these are listed in Table 16—1. Many H1 antagonists are currently mar- In pulmonary function laboratories, histamine aerosol has been keted in the USA.
A large number are available without prescrip- used as a provocative test of bronchial hyperreactivity.
These groups are distinguished by of the fish is the major causative agent. The first-generation agents are also more likely to block as part of a carefully monitored test of pulmonary function or to autonomic receptors. Second-generation H1 blockers are less patients with active ulcer disease or gastrointestinal bleeding.
All the H1 antagonists are stable amines with the general structure illustrated in Figure 16—1.
The effects of histamine released in the body can be reduced in These agents are rapidly absorbed after oral administration, with several ways.
Physiologic antagonists, especially epinephrine, peak blood concentrations occurring in 1—2 hours.
They are widely have smooth muscle actions opposite to those of histamine, but distributed throughout the body, and the first-generation drugs they act at different receptors.
This is important clinically because enter the central nervous system readily. Some of them are exten- injection of epinephrine can be lifesaving in systemic anaphylaxis sively metabolized, primarily by microsomal systems in the liver. CYP3A4 system and thus are subject to important interactions Release inhibitors reduce the degranulation of mast cells that when other drugs such as ketoconazole inhibit this subtype of results from immunologic triggering by antigen-IgE interaction.
Most of the drugs have an effective duration of Cromolyn and nedocromil appear to have this effect see Chapter 20 action of 4—6 hours following a single dose, but meclizine and sev- and have been used in the treatment of asthma, although the eral second-generation agents are longer-acting, with a duration of molecular mechanism underlying their action is not fully under- action of 12—24 hours. The newer agents are considerably less lipid- stood.
Beta2-adrenoceptor agonists also appear capable of reducing soluble than the first-generation drugs and are substrates of the histamine release.
P-glycoprotein transporter in the blood-brain barrier; as a result Histamine receptor antagonists represent a third approach to they enter the central nervous system with difficulty or not at all. For over 60 years, Many H1 antagonists have active metabolites. The active metabo- compounds have been available that competitively antagonize many lites of hydroxyzine, terfenadine, and loratadine are available as of the actions of histamine on smooth muscle.
Major features that make this book particularly useful in integrated curricula include sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects—in other words, clinical pharmacology is an integral part of this text. Lists of the commercial preparations available, including trade and generic names and dosage formulations, are provided at the end of each chapter for easy reference by the house officer or practitioner writing a chart order or prescription.
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