Q by The International Union of Biochemistry and Molecular Biology. BIOCHEMISTRY . Enter Lizabeth Allison's text, Fundamental Molecular. Biology . Editorial Reviews. About the Author. Lizabeth Allison is currently the Dorman Family Term Fundamental Molecular Biology, 2nd Edition - Kindle edition by Lizabeth A. Allison. Download it once and read it on your Kindle device, PC, phones. FMBC15 9/29/06 AM Page Chapter 15 The age of the donor nucleus may not be a consideration in some species. As an example, telomere.
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Fundamental Molecular. Biology. Lizabeth A. Allison. Department of Biology The right of Lizabeth A. Allison to be identified as the Author of this Work has been. FMBA/29/ AMPage iFundamental Molecular Biology Fundamental Molecular Biology Lizabeth A. Allison Department of Biology College of William. (c) - page 1 of 7 - Get Instant Access to PDF File: bf7e45 Fundamental Molecular Biology By Lizabeth A. Allison EPUB KINDLE.
Allison, Lizabeth A. In the early s, only two molecular biology texts were available, each with a distinctive approach to the subject. Watson's Molecular Biology of the Gene was an engaging description of the emergent ideas of molecular biology back when the core concepts contained an elegantly simple logic. Complimenting this text was Stent's Molecular Genetics: which was a brilliantly written narrative on the experiments that led to the fundamental principles of molecular biology. With the explosion of discoveries of the past 25 years, a new generation of molecular biology texts became descriptive and encyclopedic. Weaver's Molecular Biology, first published in , represented a return to presenting molecular biology via experimental analysis. However, Weaver's text is almost too rich in experimental detail for many undergraduate audiences.
A prize animal is not generally identified until it matures, so differentiated adult cells must be used for cloning.
In terms of basic research, however, cloning racehorses would provide the opportunity to test for the reproducibility of traits such as character and sporting performance. However, the heteroplasmic nature of the mtDNA in the clone would need to be taken into account. As noted in an earlier section, mitochondria inherited from the recipient egg could have a major influence over critical aspects of sporting performance, such as muscle development.
Wildlife conservation Cloning is one of several ways of increasing the number of individuals within a population when the population is in decline. Populations with low numbers of individuals have lost some genetic diversity. The example illustrates the importance of considering the source of mitochondria and hence the mitochondrial DNA when carrying out trans-species cloning by somatic cell nuclear transfer.
In this example, a domestic cow provides the oocyte egg cytoplasm, while the donor nucleus, and its accompanying cytoplasm, comes from a female of the endangered species e.
The reconstructed embryo would be a hybrid containing mitochondria from both species mitochondrial heteroplasmy. If the cloned female bred naturally with a male of the endangered species, the offspring would still have mitochondria that descended from the original donor domestic cow.
Adapted from Holt, W. Wildlife conservation and reproductive cloning.
Reproduction If individuals are cloned, in theory, this would improve the long-term fitness of the species through the retention of genetic diversity. Since current success rates with cloning by nuclear transfer are very low, hundreds of nuclear transfers might need to be performed to obtain just one offspring. This poses a problem for endangered species where it might not be possible to obtain eggs in such high numbers.
For example, the giant panda only ovulates one or two oocytes per year. Animals resulting from trans-species cloning are valuable scientifically, but are not directly useful for supporting endangered populations. Selectivity inevitably leads to omissions; so, it is also important to point out what is missing in this book. Quantitative analysis in molecular biology is almost completely absent, which is unfortunate since quantitative approaches are becoming increasingly important to understand basic molecular phenomena such as thermodynamics of DNA—DNA or DNA—protein interactions, kinetics of binding of transcription factors and RNA processing factors, topological considerations of DNA replication, as well as systems approaches to combinatorial control of gene expression.
Indeed, Chapter 3 is archaic, focusing on observations about genome organization one might have seen in a textbook 20 years ago. Even so, no discussion of the organization of sequences in genomes is discussed.
Chapter 16 focuses on the applications of genomic technologies and very little on the fundamental contributions genomics has made to our understanding of the biology of genomes. Although it is useful to integrate regulatory phenomena into mechanistic or phenomenological discussions as this and most texts do, why a separate chapter on regulation in molecular biology is absent escapes me. The end of each chapter contains 4—7 good analytical questions. The online materials are modest in scope.
One welcome feature is the availability of all the figures of the text. Also, there is a nice collection of interactive molecular structures with accompanying questions to test understanding. Hit a particularly tricky question?
Bookmark it to easily review again before an exam. The best part?
As a Chegg Study subscriber, you can view available interactive solutions manuals for each of your classes for one low monthly price. Why download extra books when you can get all the homework help you need in one place?
Can I get help with questions outside of textbook solution manuals? You bet!